Publications Print Scherer N, Fassler D, Borisov O, Cheng Y, Schlosser P, Wuttke M, Haug S, Li Y, Telkamper F, Patil S, Meiselbach H, Wong C, Berger U, Sekula P, Hoppmann A, Schultheiss UT, Mozaffari S, Xi Y, Graham R, Schmidts M, Kottgen M, Oefner PJ, Knauf F, Eckardt KU, Grunert SC, Estrada K, Thiele I, Hertel J, Kottgen A. Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits. Nat Genet. 2025 Jan; 57 (1):193-205 Epub 2025 Jan 02 View PubMed Cellini B, Baum MA, Frishberg Y, Groothoff JW, Harris PC, Hulton SA, Knauf F, Knight J, Lieske JC, Lowther WT, Moochhala S, Nazzal L, Tasian GE, Whittamore JM, Sas DJ. Opportunities in Primary and Enteric Hyperoxaluria at the Cross-Roads Between the Clinic and Laboratory. Kidney Int Rep. 2024 Nov; 9 (11):3083-3096 Epub 2024 Sept 01 View PubMed Hardenberg JB, Kunz JV, Rubarth K, Mittermaier M, Pigorsch M, Balzer F, Witzenrath M, Hinz RM, Korner R, Eckardt KU, Knauf F, Hinrichs C, Enghard P. Pre-emptive use of glucose 5% as the standard drug solvent reduces hypernatremia in critically ill patients. Clin Kidney J. 2024 Nov; 17 (11):sfae328 Epub 2024 Nov 04 View PubMed Hawkins-van der Cingel G, Walsh SB, Eckardt KU, Knauf F. Oxalate Metabolism: From Kidney Stones to Cardiovascular Disease. Mayo Clin Proc. 2024 Jul; 99 (7):1149-1161 Epub 2024 May 17 View PubMed Choi M, Kahl A, Hawkins-van der Cingel G, de las Mercedes Noriega M, Klingel K, Doeblin P, Schoenrath F, Eckardt K, Ollnger R, Knauf F, Halleck F. Recovery From Severe Heart Failure in a Patient With Primary Hyperoxaluria Type 1 After Treatment With Lumasiran, Pyridoxine, and Kidney Transplant Annals of Internal Medicine: Clinical Cases. 2024. Brosecke F, Pfau A, Ermer T, Dein Terra Mota Ribeiro AB, Rubenbauer L, Rao VS, Burlein S, Genser B, Reichel M, Aronson PS, Coca S, Knauf F. Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor. Sci Rep. 2024 May 17; 14 (1):11323 View PubMed Langman CB, Assimos D, Blank M, Calle J, Grauer A, Kausz A, Milliner D, Nazzal L, Smith K, Tasian G, Thompson A, Wood KD, Worcester E, Yang S, Malley MA, Knauf F, Lieske JC, Rare Kidney Stone Consortium (RKSC) Kidney Health Initiative (KHI) Oxalosis and Hyperoxaluria Foundation Enteric Hyperoxaluria Workgroup (OHF EH Workgroup). End Point Considerations for Clinical Trials in Enteric Hyperoxaluria. Clin J Am Soc Nephrol. 2023 Dec 1; 18 (12):1637-1644 Epub 2023 June 21 View PubMed Liu T, Dogan I, Rothe M, Kunz JV, Knauf F, Gollasch M, Luft FC, Gollasch B. Corrigendum to "Hemodialysis and Biotransformation of Erythrocyte Epoxy Fatty Acids in Peripheral Tissue". Prostaglandins Leukot Essent Fatty Acids. 2023 Dec; 198-199:102521 Epub 2022 Dec 07 View PubMed Schwab J, Wachinger J, Munana R, Nabiryo M, Sekitoleko I, Cazier J, Ingenhoff R, Favaretti C, Subramonia Pillai V, Weswa I, Wafula J, Emmrich JV, Barnighausen T, Knauf F, Knauss S, Nalwadda CK, Sudharsanan N, Kalyesubula R, McMahon SA. Design Research to Embed mHealth into a Community-Led Blood Pressure Management System in Uganda: Protocol for a Mixed Methods Study. JMIR Res Protoc. 2023 Nov 30; 12:e46614 View PubMed Sieckmann T, Schley G, Ogel N, Kelterborn S, Boivin FJ, Fahling M, Ashraf MI, Reichel M, Vigolo E, Hartner A, Lichtenberger FB, Breiderhoff T, Knauf F, Rosenberger C, Aigner F, Schmidt-Ott K, Scholz H, Kirschner KM. Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury. Kidney Int. 2023 Jul; 104 (1):90-107 Epub 2023 Apr 28 View PubMed Ingenhoff R, Munana R, Weswa I, Gaal J, Sekitoleko I, Mutabazi H, Bodnar BE, Rabin TL, Siddharthan T, Kalyesubula R, Knauf F, Nalwadda CK. Principles for task shifting hypertension and diabetes screening and referral: a qualitative study exploring patient, community health worker and healthcare professional perceptions in rural Uganda. BMC Public Health. 2023 May 12; 23 (1):881 View PubMed Kayongo A, Bartolomaeus TUP, Birkner T, Marko L, Lober U, Kigozi E, Atugonza C, Munana R, Mawanda D, Sekibira R, Uwimaana E, Alupo P, Kalyesubula R, Knauf F, Siddharthan T, Bagaya BS, Kateete DP, Joloba ML, Sewankambo NK, Jjingo D, Kirenga B, Checkley W, Forslund SK. Sputum Microbiome and Chronic Obstructive Pulmonary Disease in a Rural Ugandan Cohort of Well-Controlled HIV Infection. Microbiol Spectr. 2023 Feb 15; 11 (2):e0213921 [Epub ahead of print] View PubMed Ermer T, Nazzal L, Tio MC, Waikar S, Aronson PS, Knauf F. Oxalate homeostasis. Nat Rev Nephrol. 2023 Feb; 19 (2):123-138 Epub 2022 Nov 03 View PubMed Pfau A, Lopez-Cayuqueo KI, Scherer N, Wuttke M, Wernstedt A, Gonzalez Fassrainer D, Smith DE, van de Kamp JM, Ziegeler K, Eckardt KU, Luft FC, Aronson PS, Kottgen A, Jentsch TJ, Knauf F. SLC26A1 is a major determinant of sulfate homeostasis in humans. J Clin Invest. 2023 Feb 1; 133 (3) Epub 2023 Feb 01 View PubMed Ingenhoff R, Robertson N, Munana R, Bodnar BE, Weswa I, Sekitoleko I, Gaal J, Kirenga BJ, Kalyesubula R, Knauf F, Siddharthan T. Challenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework. Int J Chron Obstruct Pulmon Dis. 2023; 18:2769-2783 Epub 2023 Nov 28 View PubMed Lieske JC, Lingeman JE, Ferraro PM, Wyatt CM, Tosone C, Kausz AT, Knauf F. Randomized Placebo-Controlled Trial of Reloxaliase in Enteric Hyperoxaluria. NEJM Evid. 2022 Jul; 1 (7):EVIDoa2100053 Epub 2022 May 06 View PubMed Pfau A, Knauf F. Authors' Reply: Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients. J Am Soc Nephrol 2022 Jul; 33 (7):1428 Epub 2022 May 02 View PubMed Liu T, Dogan I, Rothe M, Kunz JV, Knauf F, Gollasch M, Luft FC, Gollasch B. Hemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue. Prostaglandins Leukot Essent Fatty Acids. 2022 Jun; 181:102453 Epub 2022 May 21 View PubMed Ingenhoff R, Nandawula J, Siddharthan T, Ssekitoleko I, Munana R, Bodnar BE, Weswa I, Kirenga BJ, Mutungi G, van der Giet M, Kalyesubula R, Knauf F. Effectiveness of a community health worker-delivered care intervention for hypertension control in Uganda: study protocol for a stepped wedge, cluster randomized control trial. Trials. 2022 May 24; 23 (1):440 View PubMed Liu T, Dogan I, Rothe M, Reichardt J, Knauf F, Gollasch M, Luft FC, Gollasch B. Bioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis. Metabolites. 2022 Mar 21; 12 (3) View PubMed Holthaus D, Kraft MR, Krug SM, Wolf S, Muller A, Delgado Betancourt E, Schorr M, Holland G, Knauf F, Schulzke JD, Aebischer T, Klotz C. Dissection of Barrier Dysfunction in Organoid-Derived Human Intestinal Epithelia Induced by Giardia duodenalis. Gastroenterology. 2022 Mar; 162 (3):844-858 Epub 2021 Nov 23 View PubMed Liu T, Dogan I, Rothe M, Kunz JV, Knauf F, Gollasch M, Luft FC, Gollasch B. Hemodialysis and Plasma Oxylipin Biotransformation in Peripheral Tissue. Metabolites. 2022 Jan 4; 12 (1) Epub 2022 Jan 04 View PubMed Liu J, Tio MC, Verma A, Schmidt IM, Ilori TO, Knauf F, Mc Causland FR, Waikar SS. Determinants and Outcomes Associated With Urinary Calcium Excretion in Chronic Kidney Disease. J Clin Endocrinol Metab. 2022 Jan 1; 107 (1):e281-e292 View PubMed Ingenhoff R, Brewster U, Rastegar A, Kalyesubula R, Knauf F. Global Health Education in Nephrology: The Time has Come. J Am Soc Nephrol. 2021 Dec 1; 32 (12):2990-2993 Epub 2021 Dec 01 View PubMed Siddharthan T, Kalyesubula R, Morgan B, Ermer T, Rabin TL, Kayongo A, Munana R, Anton N, Kast K, Schaeffner E, Kirenga B, Knauf F, Rural Uganda Non Communicable Disease Study Investigators. The rural Uganda non-communicable disease (RUNCD) study: prevalence and risk factors of self-reported NCDs from a cross sectional survey. BMC Public Health. 2021 Nov 7; 21 (1):2036 Epub 2021 Nov 07 View PubMed Pfau A, Ermer T, Coca SG, Tio MC, Genser B, Reichel M, Finkelstein FO, Marz W, Wanner C, Waikar SS, Eckardt KU, Aronson PS, Drechsler C, Knauf F. High Oxalate Concentrations Correlate with Increased Risk for Sudden Cardiac Death in Dialysis Patients. J Am Soc Nephrol. 2021 Sep; 32 (9):2375-2385 Epub 2021 July 19 View PubMed Batte C, Mukisa J, Rykiel N, Mukunya D, Checkley W, Knauf F, Kalyesubula R, Siddharthan T. Acceptability of patient-centered hypertension education delivered by community health workers among people living with HIV/AIDS in rural Uganda. BMC Public Health. 2021 Jul 7; 21 (1):1343 Epub 2021 July 07 View PubMed Thomson RB, Dynia DW, Burlein S, Thomson BR, Booth CJ, Knauf F, Wang T, Aronson PS. Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouse. Am J Physiol Renal Physiol. 2021 Jun 1; 320 (6):F1106-F1122 Epub 2021 May 03 View PubMed Pfau A, Grujic D, Keddis MT, Kausz AT, Lieske JC, Knauf F. Pilot study of reloxaliase in patients with severe enteric hyperoxaluria and hyperoxalemia. Nephrol Dial Transplant 2021 Apr 26; 36 (5):945-948 View PubMed Pfau A, Wytopil M, Chauhan K, Reichel M, Coca S, Aronson PS, Eckardt KU, Knauf F. Author Reply to Comment on "Assessment of Plasma Oxalate Concentration in Patients With CKD" by Oka et al. Kidney Int Rep. 2021 Apr; 6 (4):1194-1195 Epub 2021 Mar 05 View PubMed Witting C, Langman CB, Assimos D, Baum MA, Kausz A, Milliner D, Tasian G, Worcester E, Allain M, West M, Knauf F, Lieske JC. Pathophysiology and Treatment of Enteric Hyperoxaluria. Clin J Am Soc Nephrol. 2021 Mar 08; 16(3):487-495. Epub 2020 Sep 08. View PubMed Reichel M, Knauf F. Statins, obesity, and the microbiome: a potential mechanism for the pleiotropic effects of statin therapy. Kidney Int 2021 Mar; 99 (3):531-533 Epub 2020 Aug 19 View PubMed Pfau A, Wytopil M, Chauhan K, Reichel M, Coca SG, Aronson PS, Eckardt KU, Knauf F. Assessment of Plasma Oxalate Concentration in Patients With CKD. Kidney Int Rep. 2020 Nov; 5 (11):2013-2020 Epub 2020 Sept 02 View PubMed Kempf C, Pfau A, Holle J, Muller-Schluter K, Bufler P, Knauf F, Muller D. Stiripentol fails to lower plasma oxalate in a dialysis-dependent PH1 patient. Pediatr Nephrol. 2020 Sep; 35 (9):1787-1789 Epub 2020 May 16 View PubMed Neumeier LI, Thomson RB, Reichel M, Eckardt KU, Aronson PS, Knauf F. Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease. J Am Soc Nephrol. 2020 Sep; 31 (9):1987-1995 Epub 2020 July 13 View PubMed Luz HL, Reichel M, Unwin RJ, Mutig K, Najenson AC, Tonner LM, Eckardt KU, Tam FWK, Knauf F. P2X7 Receptor Stimulation Is Not Required for Oxalate Crystal-Induced Kidney Injury. Sci Rep. 2019 Dec 27; 9 (1):20086 View PubMed Egli-Spichtig D, Imenez Silva PH, Glaudemans B, Gehring N, Bettoni C, Zhang MYH, Pastor-Arroyo EM, Schonenberger D, Rajski M, Hoogewijs D, Knauf F, Misselwitz B, Frey-Wagner I, Rogler G, Ackermann D, Ponte B, Pruijm M, Leichtle A, Fiedler GM, Bochud M, Ballotta V, Hofmann S, Perwad F, Foller M, Lang F, Wenger RH, Frew I, Wagner CA. Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation. Kidney Int. 2019 Oct; 96 (4):890-905 Epub 2019 May 14 View PubMed Ferraro PM, Arrabal-Polo MA, Capasso G, Croppi E, Cupisti A, Ernandez T, Fuster DG, Galan JA, Grases F, Hoorn EJ, Knauf F, Letavernier E, Mohebbi N, Moochhala S, Petkova K, Pozdzik A, Sayer J, Seitz C, Strazzullo P, Trinchieri A, Vezzoli G, Vitale C, Vogt L, Unwin RJ, Bonny O, Gambaro G. A preliminary survey of practice patterns across several European kidney stone centers and a call for action in developing shared practice. Urolithiasis. 2019 Jun; 47 (3):219-224 Epub 2019 Mar 08 View PubMed Knauf F, Brewer JR, Flavell RA. Immunity, microbiota and kidney disease. Nat Rev Nephrol. 2019 May; 15 (5):263-274 View PubMed Chang H, Hawley NL, Kalyesubula R, Siddharthan T, Checkley W, Knauf F, Rabin TL. Challenges to hypertension and diabetes management in rural Uganda: a qualitative study with patients, village health team members, and health care professionals. Int J Equity Health. 2019 Feb 28; 18 (1):38 View PubMed Knauf F, Velazquez H, Pfann V, Jiang Z, Aronson PS. Characterization of renal NaCl and oxalate transport in Slc26a6(-/-) mice. Am J Physiol Renal Physiol. 2019 Jan 1; 316 (1):F128-F133 Epub 2018 Nov 14 View PubMed Roodnat JI, de Mik-van Egmond AME, Visser WJ, Berger SP, van der Meijden WAG, Knauf F, van Agteren M, Betjes MGH, Hoorn EJ. A Successful Approach to Kidney Transplantation in Patients With Enteric (Secondary) Hyperoxaluria. Transplant Direct. 2017 Dec; 3 (12):e331 Epub 2017 Nov 08 View PubMed Ermer T, Kopp C, Asplin JR, Granja I, Perazella MA, Reichel M, Nolin TD, Eckardt KU, Aronson PS, Finkelstein FO, Knauf F. Impact of Regular or Extended Hemodialysis and Hemodialfiltration on Plasma Oxalate Concentrations in Patients With End-Stage Renal Disease. Kidney Int Rep. 2017 Nov; 2 (6):1050-1058 Epub 2017 June 08 View PubMed Knauf F, Thomson RB, Heneghan JF, Jiang Z, Adebamiro A, Thomson CL, Barone C, Asplin JR, Egan ME, Alper SL, Aronson PS. Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion. J Am Soc Nephrol. 2017 Jan; 28 (1):242-249 Epub 2016 June 16 View PubMed Pfau A, Knauf F. Update on Nephrolithiasis: Core Curriculum 2016. Am J Kidney Dis. 2016 Dec; 68 (6):973-985 Epub 2016 Aug 03 View PubMed Ermer T, Eckardt KU, Aronson PS, Knauf F. Oxalate, inflammasome, and progression of kidney disease. Curr Opin Nephrol Hypertens. 2016 Jul; 25 (4):363-71 View PubMed Mulay SR, Eberhard JN, Pfann V, Marschner JA, Darisipudi MN, Daniel C, Romoli S, Desai J, Grigorescu M, Kumar SV, Rathkolb B, Wolf E, Hrabe de Angelis M, Bauerle T, Dietel B, Wagner CA, Amann K, Eckardt KU, Aronson PS, Anders HJ, Knauf F. Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice. Am J Physiol Renal Physiol. 2016 Apr 15; 310 (8):F785-F795 Epub 2016 Jan 13 View PubMed Darisipudi MN, Knauf F. An update on the role of the inflammasomes in the pathogenesis of kidney diseases. Pediatr Nephrol. 2016 Apr; 31 (4):535-44 Epub 2015 July 16 View PubMed Siddharthan T, Rabin T, Canavan ME, Nassali F, Kirchhoff P, Kalyesubula R, Coca S, Rastegar A, Knauf F. Implementation of Patient-Centered Education for Chronic-Disease Management in Uganda: An Effectiveness Study. PLoS One. 2016; 11 (11):e0166411 Epub 2016 Nov 16 View PubMed Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL. Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5). Aging (Albany NY). 2015 Dec; 7 (12):1086-93 View PubMed Pfau A, Eckardt KU, Knauf F. [Diagnosis and treatment of nephrolithiasis. What is established?]. Internist (Berl). 2015 Dec; 56 (12):1361-8 View PubMed Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney Int. 2013 Nov; 84 (5):895-901 Epub 2013 June 05 View PubMed Knauf F, Chaknos CM, Berns JS, Perazella MA. Dabigatran and kidney disease: a bad combination. Clin J Am Soc Nephrol. 2013 Sep; 8 (9):1591-7 Epub 2013 July 18 View PubMed Ko N, Knauf F, Jiang Z, Markovich D, Aronson PS. Sat1 is dispensable for active oxalate secretion in mouse duodenum. Am J Physiol Cell Physiol. 2012 Jul 1; 303 (1):C52-7 Epub 2012 Apr 18 View PubMed Knauf F, Ko N, Jiang Z, Robertson WG, Van Itallie CM, Anderson JM, Aronson PS. Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J Am Soc Nephrol. 2011 Dec; 22 (12):2247-55 Epub 2011 Oct 21 View PubMed Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, Konig J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT, Shulman GI. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab. 2011 Aug 3; 14 (2):184-95 View PubMed Knauf F, Preisig PA. Drosophila: a fruitful model for calcium oxalate nephrolithiasis? Kidney Int 2011 Aug; 80 (4):327-9 View PubMed Knauf F, Aronson PS. ESRD as a window into America's cost crisis in health care. J Am Soc Nephrol. 2009 Oct; 20 (10):2093-7 Epub 2009 Sept 03 View PubMed Knauf F, Desir GV, Perazella MA. A case of extreme hemodynamic lability and hypocalcemia. Am J Med Sci. 2009 Sep; 338 (3):241-4 View PubMed Knauf F, Mohebbi N, Teichert C, Herold D, Rogina B, Helfand S, Gollasch M, Luft FC, Aronson PS. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates. Biochem J. 2006 Jul 1; 397 (1):25-9 View PubMed Girardi AC, Knauf F, Demuth HU, Aronson PS. Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells. Am J Physiol Cell Physiol. 2004 Nov; 287 (5):C1238-45 Epub 2004 June 22 View PubMed Knauf F, Rogina B, Jiang Z, Aronson PS, Helfand SL. Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proc Natl Acad Sci U S A. 2002 Oct 29; 99 (22):14315-9 Epub 2002 Oct 21 View PubMed Knauf F, Yang CL, Thomson RB, Mentone SA, Giebisch G, Aronson PS. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001 Jul 31; 98 (16):9425-30 Epub 2001 July 17 View PubMed PST-20582456 Home Publications